Brinster R L
Cancer Res. 1976 Sep;36(9 PT 2):3412-4.
Teratocarcinoma cells (OTT 6050) from 129 SvSl C P mice were transferred into blastocysts from random bred Swiss albino mice. The blastocysts were placed in the uteri of foster mothers and the adults resulting from these blastocysts were studied for evidence of an effect of the transferred malignant cells. Sixty adults resulted from the experiments, and one of the adult mice that had received teratocarcinoma cells in the blastocyst stage showed several stripes of agouti hair. All the adult animals received grafts of skin from animals identical to those supplying the cells. The animals that resulted from blastocysts into which cells had been transferred maintained skin grafts for a significantly longer period than did controls. These experiments indicate that the transferred malignant cells were able to establish small colonies in the embryos and that some of these cells persisted into the adult.
将来自129 SvSl C P小鼠的畸胎瘤细胞（OTT 6050）移植到随机繁殖的瑞士白化小鼠的囊胚中。将这些囊胚置于代孕母鼠的子宫内，并对由这些囊胚发育而来的成年小鼠进行研究，以寻找移植的恶性细胞产生影响的证据。实验产生了60只成年小鼠，其中一只在囊胚期接受了畸胎瘤细胞的成年小鼠出现了几条刺鼠毛色条纹。所有成年动物都接受了与提供细胞的动物相同的动物的皮肤移植。与对照组相比，由移植了细胞的囊胚发育而来的动物维持皮肤移植的时间明显更长。这些实验表明，移植的恶性细胞能够在胚胎中建立小菌落，并且其中一些细胞持续存在到成年期。
