革兰氏阴性菌中的外排泵与耐药性

Efflux pumps and drug resistance in gram-negative bacteria.

作者信息

Ma D, Cook D N, Hearst J E, Nikaido H

机构信息

Dept of Chemistry, University of California, Berkeley 94720.

出版信息

Trends Microbiol. 1994 Dec;2(12):489-93. doi: 10.1016/0966-842x(94)90654-8.

DOI:10.1016/0966-842x(94)90654-8

PMID:7889326

Abstract

The outer membrane of Gram-negative bacteria can only slow down the influx of lipophilic inhibitors, and so these bacteria need active efflux pumps of broad specificity to survive. Pumps such as the Escherichia coli Acr system and its homologs make Gram-negative bacteria resistant to dyes, detergents and antibiotics.

摘要

革兰氏阴性菌的外膜只能减缓亲脂性抑制剂的流入，因此这些细菌需要具有广泛特异性的主动外排泵才能存活。诸如大肠杆菌Acr系统及其同源物之类的泵使革兰氏阴性菌对染料、去污剂和抗生素具有抗性。