1p单体性与脑膜瘤体内葡萄糖代谢增强相关。

Monosomy 1p is correlated with enhanced in vivo glucose metabolism in meningiomas.

作者信息

Henn W, Cremerius U, Heide G, Lippitz B, Schröder J M, Gilsbach J M, Büll U, Zang K D

机构信息

Institute of Human Genetics, University of the Saar, Homburg/Saar, Germany.

出版信息

Cancer Genet Cytogenet. 1995 Feb;79(2):144-8. doi: 10.1016/0165-4608(94)00135-x.

DOI:10.1016/0165-4608(94)00135-x

PMID:7889508

Abstract

The 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake of 25 human meningiomas was preoperatively evaluated in vivo by positron-emission tomography (PET). After surgery, meningioma biopsies were analyzed cytogenetically. Five meningiomas showed partial monosomy for chromosome 1p additional to other typical chromosome aberrations. This aberrant karyotype was correlated with increased FDG uptake. Three of five meningiomas with monosomy 1p were classified as grade II according to WHO, while only one of 20 tumors without monosomy 1p was classified as grade II. Thus, monosomy 1p and elevated FDG uptake in PET are to be regarded as cytogenetic and metabolic parameters for the aggressiveness of meningiomas.

摘要

通过正电子发射断层扫描（PET）对25例人类脑膜瘤的2-[18F]氟-2-脱氧-D-葡萄糖（FDG）摄取情况进行了术前体内评估。术后，对脑膜瘤活检组织进行了细胞遗传学分析。5例脑膜瘤除其他典型染色体畸变外，还显示1号染色体短臂部分单体性。这种异常核型与FDG摄取增加相关。5例1号染色体短臂单体性的脑膜瘤中有3例根据世界卫生组织（WHO）分类为Ⅱ级，而20例无1号染色体短臂单体性的肿瘤中只有1例分类为Ⅱ级。因此，1号染色体短臂单体性和PET中FDG摄取增加应被视为脑膜瘤侵袭性的细胞遗传学和代谢参数。