Martínez J L, Blázquez J, Baquero F
Centro Nacional de Biotecnología, Universidad Autónoma de Madrid, Cantoblanco, Spain.
Eur J Clin Microbiol Infect Dis. 1994 Dec;13(12):1015-22. doi: 10.1007/BF02111820.
Although the current in vitro methods used for detection and analysis of the phenotypes of antibiotic resistance in the laboratory are well established, other resistance mechanisms of resistance exist which may escape detection using the standard approach. The present article reviews some of these mechanisms which are grouped under the term 'non-canonical mechanisms' of antibiotic resistance. Such mechanisms include gene dosage, heterologous induction or selection, populational resistance and synergism between mechanisms of low resistance. The role of these mechanisms in the failure of therapy is discussed.
虽然目前实验室中用于检测和分析抗生素耐药表型的体外方法已经成熟,但还存在其他耐药机制,使用标准方法可能无法检测到。本文综述了其中一些机制,这些机制被归类为抗生素耐药的“非经典机制”。此类机制包括基因剂量、异源诱导或选择、群体耐药以及低耐药机制之间的协同作用。文中讨论了这些机制在治疗失败中的作用。