Nicolini U, Kustermann A, Tassis B, Fogliani R, Galimberti A, Percivalle E, Grazia Revello M, Gerna G
First Department of Obstetrics and Gynaecology, University of Milano, Italy.
Prenat Diagn. 1994 Oct;14(10):903-6. doi: 10.1002/pd.1970141002.
Fifteen fetuses at risk of congenital human cytomegalovirus (HCMV) infection underwent prenatal diagnosis at 16-30 weeks' gestation by a combination of amniocentesis and fetal blood sampling. HCMV was isolated from the amniotic fluid in six patients, but HCMV-specific IgM was detected in only three of them. Two of the nine neonates, who were delivered following a negative prenatal diagnosis, had congenital HCMV infection diagnosed by virus isolation in the urine. The interval from infection to prenatal testing was 3 and 4 weeks in the two false-negative cases and > or = 7 weeks in the true-positive cases. Although timely testing for HCMV infection allows the option of termination of pregnancy, it may be flawed by false-negative results.
15例有先天性人巨细胞病毒（HCMV）感染风险的胎儿在妊娠16至30周时通过羊膜穿刺术和胎儿采血联合进行产前诊断。6例患者的羊水分离出HCMV，但其中仅3例检测到HCMV特异性IgM。9例产前诊断为阴性后分娩的新生儿中，有2例通过尿液病毒分离诊断为先天性HCMV感染。2例假阴性病例中从感染到产前检测的间隔为3周和4周，真阳性病例中该间隔≥7周。尽管及时检测HCMV感染可选择终止妊娠，但可能存在假阴性结果的缺陷。
