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[慢性疲劳综合征]

[The chronic fatigue syndrome].

作者信息

Artsimovich N G, Chugunov V S, Kornev A V, Ivanova T M, Chugunov A V, Oprishchenko M A

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1994;94(5):47-50.

PMID:7900453
Abstract

CFIDS (chronic fatigue and immune disfunction syndrome) is also known as CFS (chronic fatigue syndrome), CEBV (chronic Epstein-Barr virus), M.E. (myalgic encephalomyelitis), yuppie flu and by other names. It is a complex illness characterized by incapacitating fatigue (experienced as exhaustion and extremely poor stamina), neurological problems and a constellation of symptoms that can resemble many disorders, including; mononucleosis, multiple sclerosis, fibromyalgia, AIDS-related complex (ARC) and autoimmune diseases such as lupus. These symptoms tend to wax and wane, but any often severely debilitating and may last for many months or years. All sections of the population (including children) are at risk, but women under 45 seem to be most susceptible. The investigators suggest that CFIDS results from dysfunction of the immune system. The exact nature of this dysfunction is not yet well defined, but it can generally be viewed as an unregulated or overactive state which is responsible for most of the symptoms. There is also evidence of some immune suppression in CFIDS. None of the treatments is consistently satisfactory, but some may be helpful: psychotherapy, physiotherapy, exercise programs, acupunctures, small doses of antidepressants, etc.

摘要

慢性疲劳及免疫功能紊乱综合征(CFIDS)也被称为慢性疲劳综合征(CFS)、慢性EB病毒感染(CEBV)、肌痛性脑脊髓炎(M.E.)、雅皮士流感等。它是一种复杂的疾病,其特征为使人丧失能力的疲劳(表现为疲惫和极度缺乏耐力)、神经问题以及一系列可能类似于多种病症的症状,包括单核细胞增多症、多发性硬化症、纤维肌痛、艾滋病相关综合征(ARC)以及自身免疫性疾病如狼疮。这些症状往往会时好时坏,但通常会严重使人衰弱,且可能持续数月或数年。所有人群(包括儿童)都有患病风险,但45岁以下的女性似乎最为易感。研究人员认为慢性疲劳及免疫功能紊乱综合征是免疫系统功能失调所致。这种功能失调的确切性质尚未明确界定,但总体上可视为一种不受控制或过度活跃的状态,它导致了大多数症状。也有证据表明慢性疲劳及免疫功能紊乱综合征存在一定程度的免疫抑制。目前没有哪种治疗方法始终令人满意,但有些方法可能会有帮助:心理治疗、物理治疗、运动计划、针灸、小剂量抗抑郁药等。

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