苍白球Fos蛋白表达的多巴胺D2受体调控：完整半球与6-羟基多巴胺处理半球的比较

Dopamine D2 receptor control of pallidal fos expression: comparisons between intact and 6-hydroxydopamine-treated hemispheres.

作者信息

Marshall J F, Cole B N, LaHoste G J

机构信息

Department of Psychobiology, University of California at Irvine 92717-4550.

出版信息

Brain Res. 1993 Dec 31;632(1-2):308-13. doi: 10.1016/0006-8993(93)91166-p.

DOI:10.1016/0006-8993(93)91166-p

PMID:7908600

Abstract

Fos expression in the globus pallidus (GP) of rats was elicited by the D2 agonist quinpirole both ipsilateral and contralateral to a unilateral nigrostriatal 6-hydroxydopamine (6-OHDA) injection; however, the 6-OHDA-treated hemisphere was more sensitive to this effect. The quinpirole-induced GP Fos expression was antagonized in both hemispheres by the D2 antagonist eticlopride, but not by the D1 antagonist SCH 23390. In neurologically intact rats, the D1 agonist SKF 38393, which alone did not elicit pallidal Fos expression, augmented the quinpirole-induced Fos response. Thus, D1 agonists can synergize with D2 agonists in inducing GP c-fos; but the D2-stimulated induction does not depend on concurrent D1 agonism.

摘要

在单侧黑质纹状体注射6-羟基多巴胺（6-OHDA）的大鼠中，D2激动剂喹吡罗可引起同侧和对侧苍白球（GP）中的Fos表达；然而，经6-OHDA处理的半球对这种效应更敏感。D2拮抗剂依托必利可拮抗喹吡罗诱导的两侧半球GP Fos表达，但D1拮抗剂SCH 23390则无此作用。在神经功能正常的大鼠中，单独使用时不会引起苍白球Fos表达的D1激动剂SKF 38393增强了喹吡罗诱导的Fos反应。因此，D1激动剂可与D2激动剂协同诱导GP中的c-fos；但D2刺激诱导并不依赖于同时存在的D1激动作用。