Pick M J, Hatch D J, Kerr A A
Br J Anaesth. 1976 Oct;48(10):983-7. doi: 10.1093/bja/48.10.983.
The effect of positive end expiratory pressure (PEEP) during mechanical ventilation of the lungs was measured in 10 young children, aged 3 weeks to 30 months, who were being ventilated artificially after cardiopulmonary bypass surgery. Changes in the end-tidal lung volume were measured directly using a jacket plethysmograph, and were assumed to indicate change in functional residual capacity (FRC). Simultaneous changes in compliance and blood-gases were measured also. FRC was increased in all subjects, and in most this increase was accompanied by an increase in arterial oxygenation. There was no significant alteration in the mean values of dynamic or static compliance in the group, although dynamic compliance increased during PEEP in six patients. PEEP may be of value after cardiopulmonary bypass in young children when oxygenation is poor despite high inspired oxygen fractions. The possible mechanisms by which it increases PaO2 are discussed.
对10名年龄在3周至30个月的幼儿进行了测量，这些幼儿在体外循环心脏手术后接受人工通气，测量了机械通气期间呼气末正压（PEEP）对肺部的影响。使用外套式体积描记器直接测量呼气末肺容积的变化，并假定其指示功能残气量（FRC）的变化。同时还测量了顺应性和血气的变化。所有受试者的FRC均增加，且大多数情况下这种增加伴随着动脉氧合的增加。该组动态或静态顺应性的平均值无显著变化，尽管6例患者在PEEP期间动态顺应性增加。在幼儿体外循环后，如果尽管吸入氧分数很高但氧合仍很差，PEEP可能有价值。讨论了其增加PaO2的可能机制。
