Keeri-Szanto M
Can Anaesth Soc J. 1976 Nov;23(6):587-95. doi: 10.1007/BF03006740.
Seventy unselected subjects were anaesthetized for major surgical operations with intravenous hydromorphone, nitrous oxide and muscle relaxants as required. The results were compared with earlier observations made with morphine under similar conditions on 44 other subjects from the same hospital population. Hydromorphone was found to be 8.5 times as potent as morphine in terms of the median surgical loading dose, and its median therapeutic half-life was 4.07 hours against morphine's 5.28 hours. It proved to be superior to morphine in its greater consistency of action. The mid-90 per cent variance of its loading dose was 30% less and the same variance of its therapeutic half-life was 65% less than that of morphine. All the differences were statistically significant or highly significant. Observations concerning the fraction of the surgical loading dose of hydromorphone required by the patients to prevent post-operative discomfort also revealed great consistency. This is taken to indicate that psychological factors play only a subordinate role in modulating the intensity of postoperative pain.
70名未经挑选的受试者接受了大手术麻醉，根据需要静脉注射氢吗啡酮、一氧化二氮和肌肉松弛剂。将结果与之前在相同条件下对同一家医院的另外44名受试者使用吗啡的观察结果进行比较。就手术中位负荷剂量而言，发现氢吗啡酮的效力是吗啡的8.5倍，其治疗中位半衰期为4.07小时，而吗啡为5.28小时。事实证明，它在作用的一致性方面优于吗啡。其负荷剂量的90% 中位数方差比吗啡小30%，其治疗半衰期的相同方差比吗啡小65%。所有差异均具有统计学意义或高度统计学意义。关于患者预防术后不适所需的氢吗啡酮手术负荷剂量比例的观察也显示出高度的一致性。这表明心理因素在调节术后疼痛强度方面仅起次要作用。
