Karege F, Widmer J, Bovier P, Gaillard J M
Institutions Universitaires de Psychiatrie de Genève, Switzerland.
Neuropsychopharmacology. 1994 May;10(3):207-14. doi: 10.1038/npp.1994.23.
Platelet serotonin and plasma tryptophan were studied in healthy subjects and in depressed patients before and during their antidepressant drug treatment. Before treatment, mean platelet serotonin level was normal in depressed patients compared with healthy subjects while a significant decrease in patients' plasma TRP was noted (t = 6.0, p < .001). The concentrations of platelet 5-HT level did not correlate with either plasma TRP or with clinical variables, that is, AMDP depression and AMDP anxiety scores. Antidepressant drugs treatment decreased platelet 5-HT level (ANOVA F = 8.27, p < .001) whatever the clinical outcome of the patient, whereas the changes observed in plasma TRP were positively related to the mood state change. These results suggest that platelet serotonin could be a good pharmacological model but has no relevance concerning the mood state.
对健康受试者以及抑郁症患者在抗抑郁药物治疗前和治疗期间的血小板血清素和血浆色氨酸进行了研究。治疗前，与健康受试者相比，抑郁症患者的平均血小板血清素水平正常，但患者血浆色氨酸水平显著降低（t = 6.0，p <.001）。血小板5-羟色胺水平的浓度与血浆色氨酸或临床变量（即AMDP抑郁和AMDP焦虑评分）均无相关性。无论患者的临床结果如何，抗抑郁药物治疗都会降低血小板5-羟色胺水平（方差分析F = 8.27，p <.001），而血浆色氨酸的变化与情绪状态变化呈正相关。这些结果表明，血小板血清素可能是一个良好的药理学模型，但与情绪状态无关。
