Dalton R R, Eisenberg B L
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Oncology (Williston Park). 1994 Jul;8(7):99-105; discussion 105-7.
Gastric resection remains the primary curative treatment for adenocarcinoma of the stomach. However, the majority of patients continue to present with advanced disease, for which curative resection is impossible. Even when curative resection is technically feasible, local and regional treatment failures are common. No successful adjuvant therapy for gastric adenocarcinoma has been developed to date. In an effort to improve the poor results of resection, "radical gastrectomy," as promoted by Japanese surgeons, has been adopted in some US centers as the primary curative operation for gastric cancer. Only a few controlled clinical trials have been conducted to evaluate the influence of the extent of resection on survival and local disease control. Until the results of current clinical trials are available, radical gastrectomy should be used selectively in the management of gastric cancer.
胃切除术仍然是胃癌的主要根治性治疗方法。然而，大多数患者就诊时仍为晚期疾病，无法进行根治性切除。即使根治性切除在技术上可行，局部和区域治疗失败也很常见。迄今为止，尚未开发出成功的胃癌辅助治疗方法。为了改善切除效果不佳的情况，美国一些中心采用了日本外科医生倡导的“根治性胃切除术”作为胃癌的主要根治性手术。仅有少数对照临床试验评估了切除范围对生存和局部疾病控制的影响。在获得当前临床试验结果之前，根治性胃切除术应在胃癌治疗中选择性使用。
