Watanabe Y, Stone E, McEwen B S
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021.
Neuroreport. 1994 Jun 27;5(11):1321-4.
Acute restraint and shaking stress each induced the mRNA for the immediate early gene (IEG), c-fos, within 1 h in locus coeruleus (LC), midbrain raphe nuclei and central gray. Both acute restraint stress and acute shaking stress activated c-fos and zif/268 mRNA in paraventricular nuclei within 1 h. Midbrain A9 and A10 dopaminergic neurons did not show any c-fos or zif/268 mRNA induction by either acute stressor. Repeated restraint stress (14d, 1h/d) produced habituation to acute restraint stress, but not to acute shaking stress, in PVN, raphe and central gray. In LC, repeated restraint stress caused some habituation to both acute stressors.
急性束缚和摇晃应激在1小时内均能诱导蓝斑（LC）、中脑缝际核和中央灰质中即早基因（IEG）c-fos的信使核糖核酸（mRNA）表达。急性束缚应激和急性摇晃应激在1小时内均能激活室旁核中的c-fos和zif/268 mRNA。中脑A9和A10多巴胺能神经元对任何一种急性应激源均未表现出c-fos或zif/268 mRNA的诱导。重复束缚应激（14天，每天1小时）使室旁核、缝际核和中央灰质对急性束缚应激产生了适应性，但对急性摇晃应激未产生适应性。在蓝斑中，重复束缚应激使对两种急性应激源均产生了一定的适应性。
