Kislitsina N S, Privalova L I, Sharapova N E
Med Tr Prom Ekol. 1993(11-12):18-20.
Chronic experiments on rats showed that the dust of silicomagnesian refractory and dunite (a raw material for refractory production) extracted in Kytlym differ insignificantly in fibrogenic activity, but rank below the quartzite extracted in Pervouralsk (MAC-1 mg/cu m). The short study analyzing the cytologic changes of bronchoalveolar lavage determined the cytotoxicity of silicomagnesian refractory and 4 other types of dunite. The estimated cytotoxicity also ranked below that of quartzite from Pervouralsk. The MAC equal to 4 mg/cu m was suggested for the group of aerosols produced by dunite and silicomagnesian refractories. These aerosols are assigned to the 3rd jeopardy class and possess basically fibrogenic activity.
对大鼠进行的慢性实验表明,在基特林提取的硅镁质耐火材料和纯橄榄岩(耐火材料生产的一种原材料)粉尘的致纤维化活性差异不显著,但低于在彼尔姆乌拉尔斯克提取的石英岩(职业接触限值为1毫克/立方米)。一项分析支气管肺泡灌洗细胞学变化的短期研究确定了硅镁质耐火材料和其他4种纯橄榄岩的细胞毒性。估计的细胞毒性也低于彼尔姆乌拉尔斯克石英岩的细胞毒性。建议将纯橄榄岩和硅镁质耐火材料产生的气溶胶组的职业接触限值设定为4毫克/立方米。这些气溶胶属于第3类危险等级,主要具有致纤维化活性。