P型钙通道参与钾离子和右芬氟拉明诱导的大鼠海马突触体释放[3H]5-羟色胺。
Involvement of P-type Ca2+ channels in the K(+)- and d-fenfluramine-induced [3H]5-HT release from rat hippocampal synaptosomes.
作者信息
Frittoli E, Gobbi M, Mennini T
机构信息
Istituto di Richerche Farmacologiche Mario Negri, Milan, Italy.
出版信息
Neuropharmacology. 1994 Jun;33(6):833-5. doi: 10.1016/0028-3908(94)90123-6.
The Ca2(+)-dependent [3H]5-HT release induced by depolarization or by 0.5 microM d-fenfluramine in rat hippocampal synaptosomes, was significantly reduced (35-42%) by three different P-type Ca2+ channels blockers (omega-Agatoxin-IVA, 100 nM, funnel-web spider toxin, FTX, 0.05 microliters/ml, and its synthetic analogue, sFTX, 1 mM), indicating the major role of these channels in the Ca2+ influx preceding neurotransmitter release.
在大鼠海马突触体中，去极化或0.5微摩尔d-芬氟拉明诱导的Ca2(+)-依赖性[3H]5-羟色胺释放，被三种不同的P型Ca2+通道阻滞剂（ω-阿加毒素-IVA，100纳摩尔，漏斗网蜘蛛毒素，FTX，0.05微升/毫升，及其合成类似物，sFTX，1毫摩尔）显著降低（35%-42%），表明这些通道在神经递质释放之前的Ca2+内流中起主要作用。
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