Eisenstein E M, Sneller M C
Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland.
Ann Allergy. 1994 Oct;73(4):285-92; quiz 293-4.
Common variable immunodeficiency is a heterogeneous syndrome characterized by humoral immunodeficiency, recurrent bacterial infections, and a variety of immunologic abnormalities. The goal of this article is to review the pathogenesis, clinical manifestations, diagnosis, and management of common variable immunodeficiency.
References are limited to the English language literature. Sources include computerized databases and bibliographies of recent articles and books.
References that made important contributions to our understanding of the pathogenesis, clinical manifestations, diagnosis, and treatment of this disease were selected for inclusion in this review.
Common variable immunodeficiency is an idiopathic state of immune dysregulation that results in impaired antibody synthesis and the development of recurrent bacterial infections. This syndrome is also associated with a variety of autoimmune and neoplastic disorders. Effective management of these patients includes intravenous immunoglobulin replacement, vigorous treatment of infections, and readiness to promptly evaluate and treat unusual autoimmune and neoplastic complications should they appear.
普通可变型免疫缺陷是一种异质性综合征，其特征为体液免疫缺陷、复发性细菌感染以及多种免疫异常。本文的目的是综述普通可变型免疫缺陷的发病机制、临床表现、诊断及管理。
参考文献仅限于英文文献。资料来源包括计算机化数据库以及近期文章和书籍的参考文献目录。
对我们理解该疾病的发病机制、临床表现、诊断及治疗有重要贡献的参考文献被选入本综述。
普通可变型免疫缺陷是一种免疫调节异常的特发性状态，导致抗体合成受损及复发性细菌感染的发生。该综合征还与多种自身免疫性和肿瘤性疾病相关。对这些患者的有效管理包括静脉注射免疫球蛋白替代治疗、积极治疗感染，以及在出现自身免疫和肿瘤并发症时随时准备及时评估和处理。
