Brewerton T D, Murphy D L, Jimerson D C
Institute of Psychiatry, Medical University of South Carolina, Charleston 29425-0742.
Neuropsychopharmacology. 1994 Aug;11(1):63-71. doi: 10.1038/npp.1994.36.
A wealth of data support a role for serotonin (5-HT) function in the mediation of satiety responses, that are impaired in patients with bulimia nervosa. Testmeal results are presented in which 26 bulimic patients and 17 normal controls were given in randomized, double-blind-fashion, placebo, and the 5-HT agents m-chlorophenylpiperazine (m-CPP, 0.5 mg/kg p.o.) and L-tryptophan (L-TRP, 100 mg/kg i.v.). Three and one-half hours after drug administration, subjects were allowed to eat and lib from a standardized testmeal of 3,500 calories, after which postprandial vomiting was not allowed. M-CPP, but not L-TRP, significantly decreased meal size in the combined group, the controls, and to a lesser extent, the bulimics (P < or = .06). Maximum m-CPP concentrations were inversely correlated to the number of calories consumed in the total group. Following m-CPP, there were significant decreases in carbohydrate, protein, and fat intake in the total group of subjects. There were also trends for decreased carbohydrate and protein intake in the bulimics following m-CPP. There were trends for both m-CPP and L-TRP to reduce fat intake in the controls. Differences in the effects between m-CPP and L-TRP are likely due to differential involvement of 5-HT receptor subtypes at presynaptic and postsynaptic sites. These studies in humans confirm reports in animals that m-CPP decreases food intake, including carbohydrates, protein, and fat in a mixed testmeal.
大量数据支持血清素（5-羟色胺，5-HT）功能在饱腹感反应调节中发挥作用，而神经性贪食症患者的饱腹感反应受损。本文呈现了试验餐结果，其中26名贪食症患者和17名正常对照者以随机、双盲方式分别接受安慰剂、5-HT药物间氯苯哌嗪（m-CPP，口服0.5mg/kg）和L-色氨酸（L-TRP，静脉注射100mg/kg）。给药后3.5小时，让受试者进食一份3500卡路里的标准化试验餐，进食后不允许餐后呕吐。m-CPP而非L-TRP显著减小了合并组、对照组以及程度稍轻的贪食症患者组的进餐量（P≤0.06）。m-CPP的最大浓度与总组中消耗的卡路里数量呈负相关。服用m-CPP后，受试者总组的碳水化合物、蛋白质和脂肪摄入量均显著减少。m-CPP给药后，贪食症患者的碳水化合物和蛋白质摄入量也有减少趋势。m-CPP和L-TRP在对照组中均有降低脂肪摄入量的趋势。m-CPP和L-TRP作用效果的差异可能是由于5-HT受体亚型在突触前和突触后位点的参与情况不同。这些人体研究证实了动物研究中的报告，即m-CPP会减少混合试验餐中的食物摄入量，包括碳水化合物、蛋白质和脂肪。
