Salvadori B, Saccozzi R, Manzari A, Andreola S, Conti R A, Cusumano F, Grassi M
Division of Surgical Oncology C, National Cancer Institute, Milan, Italy.
Eur J Cancer. 1994;30A(7):930-5. doi: 10.1016/0959-8049(94)90117-1.
A statistical analysis was performed on a series of 170 consecutive cases of operable (M0) breast cancer in males. All the patients underwent surgery. The end-points considered were: (i) overall mortality, (ii) all neoplastic events and deaths without evidence of breast disease (first event). Five- and ten-year overall mortalities were 26.9 and 54.3%, respectively. A multiple regression analysis showed that tumour size and nodal status (pT and pN) were statistically significant as prognostic factors. With regard to first events, 12 local recurrences (thoracic wall), one nodal relapse in the axilla and one contralateral tumour were observed. Primary tumours, other than breast cancer, occurred in 11 patients. The observed probability of surviving at 10 years from the treatment was definitely lower than that of the general population. For the follow-up periods of 0-5 and 6-10 years, the excess death rate per 100 man-years was 9.98 and 13.43, respectively. It appears from the analysis that prognosis of breast cancer is worse in men than in women.
对170例连续的男性可手术治疗（M0）乳腺癌病例进行了统计分析。所有患者均接受了手术。所考虑的终点指标为：（i）总死亡率，（ii）所有肿瘤事件以及无乳腺疾病证据的死亡（首次事件）。5年和10年总死亡率分别为26.9%和54.3%。多元回归分析表明，肿瘤大小和淋巴结状态（pT和pN）作为预后因素具有统计学意义。关于首次事件，观察到12例局部复发（胸壁）、1例腋窝淋巴结复发和1例对侧肿瘤。11例患者发生了除乳腺癌之外的原发性肿瘤。从治疗开始10年的观察到的生存概率明显低于一般人群。在0至5年和6至10年的随访期内，每100人年的超额死亡率分别为9.98和13.43。分析表明，男性乳腺癌的预后比女性差。
