Okamoto Y, Ota K
Department of Laboratory Medicin, Wakayama Medical College.
Nihon Rinsho. 1994 Sep;52(9):2295-300.
We summarized the changes of humoral factors, vitamin D, parathyroid hormone, and calcitonin in blood concentration, which are cooperatively regulating calcium homeostasis in aging and osteoporosis. Although these factors may play a important role on pathogenesis of osteoporosis in aged and postmenopausal osteoporotic patients, the influence of these factors on the mechanism of age-related or postmenopausal bone loss is unclear. There is no characteristic change of these factors in blood because of heterogeneity of osteoporosis and it is controversial. Further studies are required to evaluate the state of osteoporosis.
我们总结了体液因子、维生素D、甲状旁腺激素和降钙素血浓度的变化，这些因子共同调节衰老和骨质疏松症中的钙稳态。尽管这些因子可能在老年和绝经后骨质疏松症患者骨质疏松的发病机制中起重要作用，但这些因子对与年龄相关或绝经后骨质流失机制的影响尚不清楚。由于骨质疏松症的异质性，这些因子在血液中没有特征性变化，这一点存在争议。需要进一步研究来评估骨质疏松症的状态。
