西沙必利对吲哚美辛所致大鼠胃黏膜血流动力学障碍的保护作用。

Protective effect of cisapride against indomethacin-induced obstruction of the gastric mucosal hemodynamics in rats.

作者信息

Yokoyama T, Kitazawa T, Ishii A, Ogihara T, Sato N, Karasawa A

机构信息

Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.

出版信息

Jpn J Pharmacol. 1994 Jun;65(2):171-3. doi: 10.1254/jjp.65.171.

DOI:10.1254/jjp.65.171

PMID:7967230

Abstract

We investigated the effect of cisapride, a gastroprokinetic agent, on the obstructed gastric mucosal hemodynamics induced by indomethacin using an organ reflectance spectrophotometry system in rats. Indomethacin (10 mg/kg, i.v.) reduced both the gastric mucosal blood volume and the gastric mucosal blood oxygenation. Pretreatment with cisapride (0.1 mg/kg, i.v.) prevented these deteriorations. The presently-clarified gastric mucosal protective effect of cisapride may contribute to its therapeutic efficacy.

摘要

我们使用大鼠器官反射分光光度法系统，研究了促胃肠动力药西沙必利对吲哚美辛诱导的胃黏膜血流动力学障碍的影响。吲哚美辛（10毫克/千克，静脉注射）可降低胃黏膜血容量和胃黏膜血氧饱和度。西沙必利预处理（0.1毫克/千克，静脉注射）可防止这些恶化。目前已明确的西沙必利对胃黏膜的保护作用可能有助于其治疗效果。