Pharmacokinetics of multiple-dose administered gentamicin to unilaterally nephrectomized rabbits.

The aim of this study was to investigate the effect of unilateral nephrectomy on the pharmacokinetics of gentamicin. The study was carried out on 19 male rabbits. Gentamicin was injected i.v. at a dose of 3.5 mg/kg twice daily during 5 days, before operation and after 2 weeks as well as 3 months from nephrectomy. Blood for the assays was collected within 6 hours after the drug administration on the 5th day of each study stage. The immunofluorescence polarization method was employed for determination of gentamicin concentration. The one-compartment open model was used for calculations. It was shown that in unilaterally nephrectomized rabbits the elimination of gentamicin can be significantly impaired during the whole study period.