苏格兰梗犬中一种伴有中枢轴索性神经病的震颤综合征。

A tremor syndrome with a central axonopathy in Scottish terriers.

作者信息

Van Ham L, Vandevelde M, Desmidt M, Tshamala M, De Schaepdrijver L, Mattheeuws D

机构信息

Department of Small Animal Medicine, Ghent University, Belgium.

出版信息

J Vet Intern Med. 1994 Jul-Aug;8(4):290-2. doi: 10.1111/j.1939-1676.1994.tb03235.x.

DOI:10.1111/j.1939-1676.1994.tb03235.x

PMID:7983626

Abstract

A central axonopathy in 2 male and 1 female Scottish Terrier puppies from 3 different but related litters is reported. Clinical signs consisting of severe whole-body tremors and ataxia were first detected at the age of 10 to 12 weeks. They worsened with activity and excitement and diminished during rest or sleep. Two dogs also had paraparesis. In 1 dog the neurological deficits progressed over several months. Neuropathological examination revealed widespread axonal changes, vacuolation, and gliosis in the white matter of the central nervous system.

摘要

据报道，来自3窝不同但有亲缘关系的幼犬中有2只雄性和1只雌性苏格兰梗犬出现中枢轴索性神经病。临床症状包括严重的全身震颤和共济失调，最早在10至12周龄时被发现。这些症状在活动和兴奋时加重，在休息或睡眠时减轻。2只狗还出现了轻截瘫。在1只狗中，神经功能缺损在几个月内逐渐进展。神经病理学检查显示中枢神经系统白质中广泛存在轴突改变、空泡形成和胶质细胞增生。