维拉必利在人体小肠中存在第二个吸收部位的证据。新型药物递送遥测穿梭系统的应用。
Evidence for a second site of absorption of veralipride in the human small intestine. Use of a new drug delivery telemetric shuttle.
作者信息
Staveris S, Houin G, Dufour A, Plusquellec Y, Grenier J F, Jung L, Koffel J C, Saivin S
机构信息
Unité de Pharmacocinétique Clinique, Centre Hospitalier de Recherches de Purpan, France.
出版信息
Arzneimittelforschung. 1994 Sep;44(9):1068-72.
A new telemetric shuttle was used to coadminister veralipride (CAS 66644-81-3) and veralipride-D3 in order to test the assumption that veralipride is absorbed at two sites of the small intestine. Two different pharmacokinetic approaches were used to interpret the obtained data. According to the results, the second site of absorption of veralipride is located at a distance corresponding to 2/3 of the total length of the small intestine.
使用一种新型遥测穿梭装置同时给予维拉必利（化学物质登记号66644-81-3）和维拉必利-D3，以检验维拉必利在小肠两个部位吸收的假设。采用两种不同的药代动力学方法来解释所获得的数据。根据结果，维拉必利的第二个吸收部位位于距离相当于小肠总长度2/3处。
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