两名接受他莫昔芬治疗乳腺癌的绝经前患者出现卵巢囊肿。

Ovarian cyst formation in two pre-menopausal patients treated with tamoxifen for breast cancer.

作者信息

Shulman A, Cohen I, Altaras M M, Maymon R, Ben-Nun I, Tepper R, Beyth Y

机构信息

Department of Obstetrics and Gynaecology, Sapir Medical Centre, Kfar Saba, Israel.

出版信息

Hum Reprod. 1994 Aug;9(8):1427-9. doi: 10.1093/oxfordjournals.humrep.a138723.

DOI:10.1093/oxfordjournals.humrep.a138723

PMID:7989499

Abstract

Pre-menopausal tamoxifen treatment causes hyperoestrogen production and ovarian cyst formation. Two pre-menopausal breast cancer patients who were treated with tamoxifen developed both permanent supraphysiological oestrogen concentration and ovarian cysts. Serum oestrogen decreased to post-menopausal concentrations and ovarian cysts completely resolved during and following simultaneous treatment with tamoxifen and gonadotrophin-releasing hormone agonist (GnRHa). In pre-menopausal breast cancer patients, GnRHa may prevent possible side-effects of tamoxifen, such as ovarian cysts and supraphysiological oestrogen production.

摘要

绝经前他莫昔芬治疗会导致雌激素产生过多和卵巢囊肿形成。两名接受他莫昔芬治疗的绝经前乳腺癌患者出现了持续的超生理雌激素浓度和卵巢囊肿。在他莫昔芬与促性腺激素释放激素激动剂（GnRHa）同时治疗期间及之后，血清雌激素降至绝经后浓度，卵巢囊肿完全消退。在绝经前乳腺癌患者中，GnRHa可能预防他莫昔芬的潜在副作用，如卵巢囊肿和超生理雌激素产生。