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[应用明胶-间苯二酚-甲醛(GRF)生物胶治疗A型急性主动脉夹层——6例研究]

[Surgery of type A acute aortic dissection with gelatin-resorcin-formal (GRF) biological glue--study of six cases].

作者信息

Matsuda K, Ban T, Yamasato A

机构信息

Department of Cardiovascular Surgery, Kyoto University, School of Medicine, Japan.

出版信息

Nihon Kyobu Geka Gakkai Zasshi. 1994 Sep;42(9):1276-81.

PMID:7989784
Abstract

GFR (Gelatin-Resorcin-Formalin) glue consists of mixture of gelatin and resorcin. The mixture is hardened by the addition of medical form-aldehyde, creating tridimensional network. From August 1991 to February 1993, six patients of type A acute aortic dissection underwent repair of false lumen with GRF glue. Including one female, the mean age was 57.3 years old ranged 51 years old to 64 years old. The entry of aortic intima were found in the ascending aorta in 4 cases, in the greater curvature of aortic arch in one case, and in the lesser curvature of aortic arch in one case. We used GRF glue for adhesion of intimal and medial wall of dissecting aneurysm in all cases. In case 1, the ascending aorta was replaced with a ringed intraluminal graft, and in case 2, the ascending aorta was replaced with a graft. In case 3 and 4, the aortic wall was closed primarily using GRF glue after patch closure of an entry. In case 5 and 6, the ascending aorta including an aortic arch was replaced with a graft. We revealed that GRF glue could harden the thin wall of aorta in the acute phase.

摘要

GFR(明胶-间苯二酚-甲醛)胶水由明胶和间苯二酚的混合物组成。该混合物通过添加医用甲醛硬化,形成三维网络。1991年8月至1993年2月,6例A型急性主动脉夹层患者接受了用GRF胶水修复假腔的治疗。其中包括1名女性,平均年龄为57.3岁,年龄范围在51岁至64岁之间。4例患者的主动脉内膜入口位于升主动脉,1例位于主动脉弓大弯处,1例位于主动脉弓小弯处。所有病例中我们都使用GRF胶水使夹层动脉瘤的内膜和中膜壁粘连。病例1中,升主动脉被带环腔内移植物置换;病例2中,升主动脉被移植物置换。病例3和4中,在入口处补片修补后,主要使用GRF胶水封闭主动脉壁。病例5和6中,包括主动脉弓的升主动脉被移植物置换。我们发现GRF胶水可使急性期的主动脉薄壁硬化。

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