什么定义了多能造血干细胞（PHSC）：真正的PHSC能站出来吗！ - Suppr

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What defines a pluripotent hematopoietic stem cell (PHSC): will the real PHSC please stand up!

作者信息

Orlic D, Bodine D M

出版信息

Blood. 1994 Dec 15;84(12):3991-4.

PMID:7994018

Abstract

摘要

相似文献

What defines a pluripotent hematopoietic stem cell (PHSC): will the real PHSC please stand up!什么定义了多能造血干细胞（PHSC）：真正的PHSC能站出来吗！

Blood. 1994 Dec 15;84(12):3991-4.

Efficient retrovirus transduction of mouse pluripotent hematopoietic stem cells mobilized into the peripheral blood by treatment with granulocyte colony-stimulating factor and stem cell factor.通过粒细胞集落刺激因子和干细胞因子治疗动员到外周血中的小鼠多能造血干细胞的高效逆转录病毒转导

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Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.PU.1基因的靶向破坏导致多种造血异常。

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Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7.多能造血干细胞含有高水平的c-kit、GATA-2、p45 NF-E2和c-myb的mRNA，而c-fms以及粒细胞集落刺激因子和白细胞介素5和7的受体的mRNA水平较低或没有。

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