[Inhibitory effect of interferon on expression of oncogene in over-proliferative smooth muscle cell].

The model of balloon angioplasty (BA) was founded in rabbit abdominal aorta. In situ hybridization was used with the probes of oncogenes c-fos, c-myc and N-ras labeled by digoxin in vessel segments after BA and with the probes of oncogenes c-fos, c-myc, and N-ras labeled by biotin in smooth muscle cell (SMC) irritated by cultured medium of vessel segments after BA. Overexpression of c-fos, c-myc and N-ras oncogenes occurred in vessel segments after BA mainly in atherosclerotic plaques. There was expression of oncogene in normal vessel segments. Overexpression appeared in the over-proliferative SMC irritated by cultured medium of vessel segments after BA. A expression of N-ras occurred on the membrane of cellular nucleus. There was no expression of oncogenes in the normal SMC of control group. Overexpression could be partly inhibited by interferon-gamma.