Nakamura Y, Tsuji N, Taira N, Hirose H
National Institute of Animal Health, Ibaraki, Japan.
J Vet Med Sci. 1994 Aug;56(4):723-7. doi: 10.1292/jvms.56.723.
The present study was aimed at elucidating the responsibility of parasitic females for sudden cardiac death following Strongyloides papillosus infection in calves. A preliminary experiment demonstrated a percutaneous infection with S. papillosus infective larvae to cause sudden cardiac death in lambs as in calves, indicating lambs could serve as a model to study fatal stronglyloidiasis in calves. Parasitic females of S. papillosus were inoculated into the duodenum of lambs. Lambs given live worms developed continuous sinus tachycardia immediately after inoculation, and died of sudden cardiac arrest by ventricular fibrillation through a phase of the disease identical to the case of percutaneous larval infection. The lambs had high fecal egg counts at the time of death. Inoculation of homogenized worms did not produce fatal arrhythmias. These results demonstrate that live parasitic females of S. papillosus in the small intestine are responsible for cardiac dysfunction regardless of the presence or absence of migratory larvae.
本研究旨在阐明乳头类圆线虫感染犊牛后，寄生雌虫在犊牛心源性猝死中的作用。一项初步实验表明，经皮感染乳头类圆线虫感染性幼虫会导致羔羊像犊牛一样发生心源性猝死，这表明羔羊可作为研究犊牛致命类圆线虫病的模型。将乳头类圆线虫的寄生雌虫接种到羔羊的十二指肠内。接种活虫的羔羊在接种后立即出现持续性窦性心动过速，并在疾病的一个阶段因心室颤动而死于心搏骤停，这一阶段与经皮幼虫感染的情况相同。羔羊死亡时粪便中的虫卵计数很高。接种匀浆虫体并未产生致命性心律失常。这些结果表明，无论是否存在移行幼虫，小肠内活的乳头类圆线虫寄生雌虫均是导致心脏功能障碍的原因。
