他莫昔芬对绝经后乳腺癌女性脂质过氧化物及抗氧化系统的影响。
Effect of tamoxifen on lipid peroxide and antioxidative system in postmenopausal women with breast cancer.
作者信息
Thangaraju M, Vijayalakshmi T, Sachdanandam P
机构信息
Department of Medical Biochemistry, University of Madras, India.
出版信息
Cancer. 1994 Jul 1;74(1):78-82. doi: 10.1002/1097-0142(19940701)74:1<78::aid-cncr2820740114>3.0.co;2-l.
BACKGROUND
Current evidence clearly indicates that free radicals play a prominent role in the incidence and development of breast cancer. Available literature suggests that tamoxifen is a potent suppressor of lipid peroxide formation in both animal and human systems. The purpose of this study was to understand the rate of lipid peroxidation and the status of antioxidants in tamoxifen-treated postmenopausal women with breast cancer.
METHODS
A short term evaluation of 6 months' tamoxifen therapy (10 mg twice a day) in 64 postmenopausal women was conducted. The rate of serum lipid peroxidation and the status of enzymic and nonenzymic antioxidants were evaluated before and after 3 and 6 months' tamoxifen treatment.
RESULTS
At 3 and 6 months' evaluation, tamoxifen-treated patients showed a significantly decreased concentration of malondialdehyde (P < 0.001), an end product of lipid peroxidation, and remarkably increased levels of enzymic and nonenzymic antioxidants. In addition to that, the concentrations of serum selenium and vitamins A, C, and E were increased significantly (P < 0.01 for each) in these patients.
CONCLUSION
The results suggest that tamoxifen therapy exerts significant positive effects on the rate of lipid peroxidation and protective systems in postmenopausal women with breast cancer.
背景
目前的证据清楚地表明，自由基在乳腺癌的发生和发展中起着重要作用。现有文献表明，他莫昔芬在动物和人体系统中都是脂质过氧化物形成的有效抑制剂。本研究的目的是了解他莫昔芬治疗的绝经后乳腺癌妇女的脂质过氧化速率和抗氧化剂状态。
方法
对64名绝经后妇女进行了为期6个月的他莫昔芬治疗（每天两次，每次10毫克）的短期评估。在他莫昔芬治疗3个月和6个月前后，评估血清脂质过氧化速率以及酶促和非酶促抗氧化剂的状态。
结果
在3个月和6个月的评估中，接受他莫昔芬治疗的患者脂质过氧化终产物丙二醛的浓度显著降低（P < 0.001），酶促和非酶促抗氧化剂水平显著升高。除此之外，这些患者血清硒以及维生素A、C和E的浓度显著增加（各P < 0.01）。
结论
结果表明，他莫昔芬治疗对绝经后乳腺癌妇女的脂质过氧化速率和保护系统具有显著的积极作用。
Zotero 插件