Stein J, Scheuermann E H, Yazdi R, Lembcke B, Caspary W F
Division of Gastroenterology, Johann Wolfgang Goethe-University, Frankfurt/Main.
Z Gastroenterol. 1994 Apr;32(4):236-9.
The intestinal mucosa plays a fundamental role as the site for absorption of nutrients, and as an important barrier against potentially harmful agents in the gastrointestinal lumen. The functional integrity of the small bowel in patients with chronic renal failure was measured by post-heparin-diaminoxidase (DAO) activity in a low and safe dose of heparin (5000 IU) in patients with chronic renal failure participating in a hemodialysis program. The results of the study provide one of the first observations about a diminished DAO-response in patients with chronic renal failure reflecting a mucosal abnormality in these patients which has to be further characterized. Our findings also show that this reduced DAO activity is not caused by the effect of uremic toxins. These results further show that a smaller and safer i.v. dose of heparin (5000 IU or less) will release DAO activity as reliably as high doses used by others. We therefore conclude that postheparin DAO activity might be used as a new noninvasive test reflecting intestinal function in patients with chronic renal failure.
肠黏膜作为营养物质吸收的场所，以及作为胃肠道管腔内潜在有害物质的重要屏障，发挥着重要作用。在参与血液透析项目的慢性肾衰竭患者中，通过低剂量安全剂量肝素（5000国际单位）后的肝素二胺氧化酶（DAO）活性来测量慢性肾衰竭患者小肠的功能完整性。该研究结果首次观察到慢性肾衰竭患者的DAO反应减弱，这反映了这些患者的黏膜异常，有待进一步明确。我们的研究结果还表明，这种DAO活性降低并非由尿毒症毒素的作用引起。这些结果进一步表明，较小且更安全的静脉注射肝素剂量（5000国际单位或更低）与其他人使用的高剂量一样能可靠地释放DAO活性。因此，我们得出结论，肝素后DAO活性可能用作反映慢性肾衰竭患者肠道功能的一种新的非侵入性检测方法。
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