红霉素、醋竹桃霉素和泰乐菌素对兔肠道的比较研究。

Comparative study of erythromycin, troleandomycin and tylosin on the rabbit intestine.

作者信息

Kounenis G, Koutsoviti-Papadopoulou M, Elezoglou V

机构信息

Department of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University, Thessaloniki, Greece.

出版信息

Fundam Clin Pharmacol. 1994;8(2):173-7. doi: 10.1111/j.1472-8206.1994.tb00794.x.

DOI:10.1111/j.1472-8206.1994.tb00794.x

PMID:8020874

Abstract

The macrolide antimicrobial agents, erythromycin, troleandomycin and tylosin were tested for their effect on isolated whole segments of the rabbit duodenum, jejunum, ileum and ascending colon, as well as on strips of the circular and longitudinal smooth muscle of the ascending colon. The 14-membered macrolides erythromycin and troleandomycin were found to possess a concentration-dependent contractile effect on the intestinal smooth muscle. The order of potency was: erythromycin > troleandomycin. The 16-membered macrolide tylosin was found to have a much weaker potency than erythromycin and troleandomycin. In addition, the circular smooth muscle of the ascending colon was found to be more sensitive to the compounds tested than the longitudinal smooth muscle.

摘要

对大环内酯类抗菌药物红霉素、醋竹桃霉素和泰乐菌素进行了测试，观察它们对兔十二指肠、空肠、回肠和升结肠的离体全段以及升结肠环行和纵行平滑肌条的作用。发现14元大环内酯类药物红霉素和醋竹桃霉素对肠道平滑肌具有浓度依赖性收缩作用。效力顺序为：红霉素＞醋竹桃霉素。发现16元大环内酯类药物泰乐菌素的效力比红霉素和醋竹桃霉素弱得多。此外，还发现升结肠的环行平滑肌对所测试的化合物比纵行平滑肌更敏感。