Cebollero Rivas P, Garisa Rocha R, Bazo Fernández E, Colás Sanz C, Duce Gracia F
Servicio de Neumología, Hospital Clínico Universitario de Zaragoza.
Rev Clin Esp. 1994 Apr;194(4):288-90.
Theophylline has shown itself to be a useful bronchodilator in the treatment of asthma, although its use has been restricted of late due to its lesser potency and greater side effects when compared with beta-adrenergic inhalants. The objective of our study is to evaluate its clinical effectiveness in moderately severe asthma. We study 12 patients with stable chronic asthma on whom a spirometry in basal conditions was performed and after therapeutic levels of theophyllinemia were reached. Peak flow and clinical symptomatology were monitored during one-week periods in both phases of the study. Daytime and night-time symptoms were evaluated independently. No significant changes were observed in the spirometric values. No changes were observed in the bronchodilation test, the concomitant consumption of bronchodilators, or in the maximum expiratory fluids. However, significant differences were observed in the overall computation of symptoms and in the quantification of nocturnal symptoms. We conclude that retarded theophylline presents little usefulness in the treatment of asthma, even though its use can be recommended as symptomatic treatment of nocturnal asthma given its prolonged bronchodilating effect.
茶碱已证明自身是治疗哮喘的一种有用的支气管扩张剂，尽管与β - 肾上腺素能吸入剂相比，其效力较低且副作用较大，导致其近期使用受限。我们研究的目的是评估其在中度严重哮喘中的临床疗效。我们研究了12例稳定的慢性哮喘患者，在基础状态下进行了肺活量测定，并在达到治疗性血药浓度的茶碱水平后再次测定。在研究的两个阶段中，每周监测一次峰值流量和临床症状。白天和夜间症状分别进行评估。肺活量测定值未观察到显著变化。支气管扩张试验、支气管扩张剂的伴随使用量或最大呼气流量均未观察到变化。然而，在症状的总体计算和夜间症状的量化方面观察到了显著差异。我们得出结论，缓释茶碱在治疗哮喘方面作用不大，尽管鉴于其长效支气管扩张作用，可推荐将其用于夜间哮喘的对症治疗。
