溃疡性结肠炎中的自身免疫性溶血性贫血

Auto-immune haemolytic anaemia in ulcerative colitis.

作者信息

Ramakrishna R, Manoharan A

机构信息

Department of Clinical Haematology, St. George Hospital, Kogarah, Sydney, Australia.

出版信息

Acta Haematol. 1994;91(2):99-102. doi: 10.1159/000204264.

DOI:10.1159/000204264

PMID:8023653

Abstract

We report 2 patients with auto-immune haemolytic anaemia (AIHA) complicating ulcerative colitis (UC), each with a hitherto undescribed feature. In the 1st case, direct antiglobulin test showed red cells coated with complement only, and the 2nd case was successfully treated with danazol. These 2 patients bring to 40 the number of cases of AIHA associated with UC. A review of the clinical details suggests that the patients may be divided into two distinct groups. In the first (4/40), AIHA seems to occur as an auto-immune event independent of the activity of UC; in the second group (36/40), AIHA is apparently dependent on active colitis, i.e. control of colitis is crucial to control haemolysis.

摘要

我们报告了2例自身免疫性溶血性贫血（AIHA）并发溃疡性结肠炎（UC）的患者，每例都有一个迄今未被描述的特征。在第一例中，直接抗球蛋白试验显示红细胞仅被补体包被，第二例患者用达那唑成功治疗。这2例患者使与UC相关的AIHA病例数增至40例。对临床细节的回顾表明，患者可分为两个不同的组。在第一组（4/40）中，AIHA似乎是作为一种独立于UC活动的自身免疫事件发生的；在第二组（36/40）中，AIHA显然依赖于活动性结肠炎，即控制结肠炎对控制溶血至关重要。