细菌核糖体的肽基转移酶中心：底物特异性和结合位点
Peptidyl transferase centre of bacterial ribosomes: substrate specificity and binding sites.
作者信息
Krayevsky A A, Kukhanova M K, Gottikh B P
出版信息
Nucleic Acids Res. 1975 Dec;2(12):2223-36. doi: 10.1093/nar/2.12.2223.
Abstract
A detailed scheme of the Peptidyl Transferase Centre of bacterial ribosomes is proposed by summarizing the literature data on the substrate specificity of the acceptor and donor sites. According to the proposed scheme only the elements of the donor and acceptor having a stable structure bind with the ribosome. The present paper proposes such main elements for the donor and acceptor.
摘要
通过总结关于受体和供体位点底物特异性的文献数据，提出了细菌核糖体肽基转移酶中心的详细方案。根据所提出的方案，只有具有稳定结构的供体和受体元件与核糖体结合。本文提出了供体和受体的此类主要元件。
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Peptidyl transferase centre of bacterial ribosomes: substrate specificity and binding sites.细菌核糖体的肽基转移酶中心：底物特异性和结合位点
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Affinity labelling the acceptor site of the peptidyl transferase centre of the Escherichia coli ribosome.亲和标记大肠杆菌核糖体肽基转移酶中心的受体位点。
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On substrate specificity of the donor site of the Escherichia coli ribosomal peptidyl transferase center. Synthesis of dipeptides from 3'-terminal fragments of aminoacyl-tRNA.关于大肠杆菌核糖体肽基转移酶中心供体部位的底物特异性。由氨酰 - tRNA的3'末端片段合成二肽。
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The donor site of the peptidyltransferase center of ribosomes: equilibrium association constants of model substrates and inhibitors.核糖体肽基转移酶中心的供体部位：模型底物和抑制剂的平衡缔合常数。
FEBS Lett. 1979 Jun 1;102(1):198-203. doi: 10.1016/0014-5793(79)80959-x.
8
Peptidyl transferase of bacterial ribosome: resistance to proteinase K.细菌核糖体的肽基转移酶：对蛋白酶K的抗性
Eur J Biochem. 1979 Feb 1;93(3):527-33. doi: 10.1111/j.1432-1033.1979.tb12851.x.
9
Kinetic constants for model substrates of peptidyltransferase donor site of Escherichia coli ribosomes.大肠杆菌核糖体肽基转移酶供体位点模型底物的动力学常数。
FEBS Lett. 1979 Aug 15;104(2):279-83. doi: 10.1016/0014-5793(79)80832-7.
10
Stereochemical control of ribosomal peptidyltransferase reaction. Role of amino acid side-chain orientation of acceptor substrate.核糖体肽基转移酶反应的立体化学控制。受体底物氨基酸侧链取向的作用。
Biochemistry. 1981 Jan 6;20(1):8-15. doi: 10.1021/bi00504a002.
引用本文的文献
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Synthesis of acylamino acid esters of nucleoside 5'-phosphates and their investigation with PMR and CD spectra.核苷5'-磷酸的酰基氨基酸酯的合成及其核磁共振氢谱和圆二色光谱研究
Nucleic Acids Res. 1977 Jul;4(7):2223-34. doi: 10.1093/nar/4.7.2223.
2
Catalysis of the peptide bond formation by 50 S subunits of E. coli ribosomes with N-(formyl) methionine ester of adenylic acid as peptide donor.以腺苷酸的N-（甲酰）蛋氨酸酯作为肽供体，由大肠杆菌核糖体的50S亚基催化肽键形成。
Mol Biol Rep. 1976 Nov;3(2):151-6. doi: 10.1007/BF00423229.
本文引用的文献
1
PUROMYCIN INHIBITION OF PROTEIN SYNTHESIS: INCORPORATION OF PUROMYCIN INTO PEPTIDE CHAINS.嘌呤霉素对蛋白质合成的抑制作用：嘌呤霉素掺入肽链的过程。
Proc Natl Acad Sci U S A. 1964 Apr;51(4):585-92. doi: 10.1073/pnas.51.4.585.
2
The effect of puromycin on rabbit reticulocyte ribosomes.嘌呤霉素对兔网织红细胞核糖体的作用。
Biochim Biophys Acta. 1962 Jun 11;55:865-74. doi: 10.1016/0006-3002(62)90899-5.
3
3'(2')-O-Aminoacylnucleotides as polypeptide acceptors at the ribosomal peptidyltransferase center.3'（2'）-O-氨酰基核苷酸作为核糖体肽基转移酶中心的多肽受体。
FEBS Lett. 1970 Apr 2;7(2):112-113. doi: 10.1016/0014-5793(70)80133-8.
4
Synthesis of tRNA ureido derivatives as substrates for The invention of the ribosome peptidyl transferase center.作为核糖体肽基转移酶中心发明底物的tRNA脲基衍生物的合成。
FEBS Lett. 1972 Aug 1;24(2):201-203. doi: 10.1016/0014-5793(72)80767-1.
5
On the mechanism of peptide bond synthesis in the ribosome. 3'-O-phenylalanyl-2'-O-methyladenosine as a peptide acceptor.核糖体中肽键合成的机制。3'-O-苯丙氨酰基-2'-O-甲基腺苷作为肽受体。
FEBS Lett. 1972 Aug 1;24(2):177-180. doi: 10.1016/0014-5793(72)80761-0.
6
Ribosome-catalysed reaction of puromycin with a formylmethionine-containing oligonucleotide.核糖体催化嘌呤霉素与含甲酰甲硫氨酸的寡核苷酸的反应。
J Mol Biol. 1967 Apr 28;25(2):347-50. doi: 10.1016/0022-2836(67)90146-5.
7
Puromycin analogs. Aminoacyl derivatives of 9-(3'-amino-3'-deoxy-beta-D-arabino-furanosyl)adenine.嘌呤霉素类似物。9-(3'-氨基-3'-脱氧-β-D-阿拉伯呋喃糖基)腺嘌呤的氨酰基衍生物。
J Med Chem. 1970 Jul;13(4):775-7. doi: 10.1021/jm00298a058.
8
Oligonucleotide interactions. IV. Conformational differences between deoxy- and ribodinucleoside phosphates.寡核苷酸相互作用。IV. 脱氧和核糖二核苷磷酸之间的构象差异。
Biopolymers. 1970;9(9):1079-103. doi: 10.1002/bip.1970.360090910.
9
Stereochemistry of nucleic acids and their constituents. 13. The crystal and molecular structure of 3'-O-acetyladenosine. Conformational analysis of nucleosides and nucleotides with syn glycosidic torsional angle.核酸及其成分的立体化学。13. 3'-O-乙酰腺苷的晶体和分子结构。具有顺式糖苷扭转角的核苷和核苷酸的构象分析。
J Am Chem Soc. 1970 Aug 12;92(16):4963-70. doi: 10.1021/ja00719a033.
10
Inhibition of protein synthesis by aminoacyl 3'-(2')-adenosine.氨酰基3'-(2')-腺苷对蛋白质合成的抑制作用。
Biochim Biophys Acta. 1966 Jun 22;119(3):566-80. doi: 10.1016/0005-2787(66)90133-x.
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