Knipper M, da Penha Berzaghi M, Blöchl A, Breer H, Thoenen H, Lindholm D
University Stuttgart Hohenheim, Institute of Zoophysiology, Germany.
Eur J Neurosci. 1994 Apr 1;6(4):668-71. doi: 10.1111/j.1460-9568.1994.tb00312.x.
In the rat hippocampus, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are synthesized by neurons in an activity-dependent manner. Glutamate receptor activation increases whereas GABAergic stimulation decreases NGF and BDNF mRNA levels. Here we demonstrate that NGF and BDNF mRNA and NGF protein are up-regulated in the rat hippocampus by the activation of muscarinic receptors. Conversely, NGF and BDNF enhance the release of acetylcholine (ACh) from rat hippocampal synaptosomes containing the nerve endings of the septal cholinergic neurons. NGF also rapidly increases the high-affinity choline transport into synaptosomes. The reciprocal regulation of ACh, NGF and BDNF in the hippocampus suggests a novel molecular framework by which the neurotrophins might influence synaptic plasticity.
在大鼠海马体中，神经生长因子（NGF）和脑源性神经营养因子（BDNF）由神经元以活动依赖的方式合成。谷氨酸受体激活会增加，而GABA能刺激会降低NGF和BDNF的mRNA水平。在这里，我们证明毒蕈碱受体的激活会使大鼠海马体中的NGF和BDNF mRNA以及NGF蛋白上调。相反，NGF和BDNF会增强大鼠海马体突触体中乙酰胆碱（ACh）的释放，这些突触体含有隔区胆碱能神经元的神经末梢。NGF还能迅速增加高亲和力胆碱向突触体的转运。海马体中ACh、NGF和BDNF的相互调节提示了一种新的分子框架，通过该框架神经营养因子可能影响突触可塑性。
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