Welch L S, Michaels D, Zoloth S R
George Washington School of Medicine, Washington, D.C.
Am J Ind Med. 1994 May;25(5):635-48. doi: 10.1002/ajim.4700250504.
This report presents data gathered from a series of asbestos disease screening examinations of 9,605 United States sheet metal workers who were first employed in the trade at least 20 years before the examination. The overall prevalence of asbestos-related radiographic changes was 31.1%: 18.8% had pleural abnormalities alone, 6.6% had parenchymal abnormalities (International Labour Office (ILO) score of 1/0 or higher) alone, and 5.7% had both. Among those with 40 years or more since entering the trade, 41.5% had radiographic signs of asbestos-related disease, 24.2% pleural alone, 7.7% parenchymal alone, and 9.6% both pleural and parenchymal abnormalities. After controlling for several surrogates for asbestos exposure level, cigarette smoking was found to increase risk of parenchymal, and more modestly, pleural abnormalities. Each pack-year was associated with a 1% increased prevalence odds ratios for parenchymal abnormalities (ILO category 1 compared to category 0), and 0.4% increased prevalence odds ratios for pleural abnormalities. A history of shipyard employment also produced significantly increased prevalence odds ratios for each radiographic category. More that 90% of chest radiographs were classified by A or B readers; after adjustment for other risk factors, A readers were more likely to report parenchymal abnormalities of category 1, but not more likely to report category 2 or pleural abnormalities, than B readers.
本报告展示了从9605名美国钣金工人的一系列石棉疾病筛查检查中收集的数据,这些工人在检查前至少20年就首次从事该行业。石棉相关影像学改变的总体患病率为31.1%:仅胸膜异常的占18.8%,仅实质异常(国际劳工组织(ILO)评分为1/0或更高)的占6.6%,两者皆有的占5.7%。在从业40年及以上的工人中,41.5%有石棉相关疾病的影像学迹象,仅胸膜异常的占24.2%,仅实质异常的占7.7%,胸膜和实质均异常的占9.6%。在控制了几个石棉暴露水平的替代指标后,发现吸烟会增加实质异常的风险,对胸膜异常的影响则较小。每增加一包年的吸烟量,实质异常(与ILO 0类相比的1类)的患病率比值比增加1%,胸膜异常的患病率比值比增加0.4%。有造船厂工作经历也会使每个影像学类别的患病率比值比显著增加。超过90%的胸部X光片由A级或B级阅片者分类;在调整其他风险因素后,与B级阅片者相比,A级阅片者更有可能报告1类实质异常,但报告2类或胸膜异常的可能性并不更高。