腱鞘巨细胞瘤（结节性腱鞘炎）的细胞遗传学特征
Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis).
作者信息
Dal Cin P, Sciot R, Samson I, De Smet L, De Wever I, Van Damme B, Van den Berghe H
机构信息
Center for Human Genetics, University of Leuven, Belgium.
出版信息
Cancer Res. 1994 Aug 1;54(15):3986-7.
Chromosome investigation in six localized forms of tenosynovial giant cell tumors, also known as modular tenosynovitis, revealed an identical translocation between chromosomes 1 and 2, t(1;2)(p11;q35-36) in three tumors, a variant translocation t(1;5)(p11;q22) in a fourth case, and a t(2;16)(q33;q24) in a fifth case. One case showed a normal karyotype. Although morphologically rather uniform, these benign tumors appear to be cytogenetically heterogeneous, but the chromosome changes seem to cluster in 2 regions, 1p11 and 16q24.
对六种局限性腱鞘巨细胞瘤（也称为结节性腱鞘炎）进行的染色体研究显示，在三个肿瘤中存在1号和2号染色体之间相同的易位，即t(1;2)(p11;q35 - 36)，第四例为变异易位t(1;5)(p11;q22)，第五例为t(2;16)(q33;q24)。一例显示核型正常。尽管这些良性肿瘤在形态上相当一致，但在细胞遗传学上似乎具有异质性，不过染色体变化似乎集中在两个区域，即1p11和16q24。
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