慢性淋巴细胞白血病中的静脉注射免疫球蛋白
Intravenous immune globulin in chronic lymphocytic leukaemia.
作者信息
Gamm H, Huber C, Chapel H, Lee M, Ries F, Dicato M A
机构信息
Universitätsklinik Mainz, Abt. Hämatologie, Germany.
出版信息
Clin Exp Immunol. 1994 Jul;97 Suppl 1(Suppl 1):17-20.
Abstract
The most common complication of chronic lymphocytic leukaemia (CLL) is infection, which occurs mainly in advanced stages of disease or in those patients with hypogammaglobulinaemia. Intravenous immune globulin (IVIG) has been shown to be a useful prophylactic therapy against infections in such patients. A randomized, double-blind study on 36 patients receiving either 500 mg/kg or 250 mg/kg IVIG every 4 weeks was undertaken to determine the dose regimen required. There was no significant difference in the two treatment groups and we found that CLL patients were equally protected with low-dose IVIG.
摘要
慢性淋巴细胞白血病（CLL）最常见的并发症是感染，主要发生在疾病晚期或低丙种球蛋白血症患者中。静脉注射免疫球蛋白（IVIG）已被证明是针对此类患者感染的一种有效预防性治疗方法。我们进行了一项针对36例患者的随机双盲研究，这些患者每4周接受500mg/kg或250mg/kg的IVIG治疗，以确定所需的剂量方案。两个治疗组之间没有显著差异，并且我们发现低剂量IVIG对CLL患者具有同样的保护作用。
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本文引用的文献
1
A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis.一项基于多变量生存分析得出的慢性淋巴细胞白血病新预后分类。
Cancer. 1981 Jul 1;48(1):198-206. doi: 10.1002/1097-0142(19810701)48:1<198::aid-cncr2820480131>3.0.co;2-v.
2
3
Factors influencing the duration of survival of patients with chronic lymphocytic leukemia.影响慢性淋巴细胞白血病患者生存时长的因素。
Am J Med. 1966 Feb;40(2):243-54. doi: 10.1016/0002-9343(66)90105-7.
4
5
Mechanisms of infection in chronic lymphocytic leukemia.慢性淋巴细胞白血病的感染机制
Semin Hematol. 1987 Oct;24(4):291-6.
6
Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group.慢性淋巴细胞白血病临床诊疗规范：美国国立癌症研究所资助工作组的建议
Am J Hematol. 1988 Nov;29(3):152-63. doi: 10.1002/ajh.2830290307.
7
B-cell chronic lymphocytic leukaemia: clonal chromosome abnormalities and prognosis in 89 cases.B细胞慢性淋巴细胞白血病：89例的克隆性染色体异常与预后
Eur J Haematol. 1989 Nov;43(5):397-403. doi: 10.1111/j.1600-0609.1989.tb00326.x.
8
Serum immunoglobulins in B-chronic lymphocytic leukemia. Natural history and prognostic significance.B 细胞慢性淋巴细胞白血病中的血清免疫球蛋白。自然病史及预后意义。
Cancer. 1988 Jan 15;61(2):279-83. doi: 10.1002/1097-0142(19880115)61:2<279::aid-cncr2820610215>3.0.co;2-4.
9
Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities.由特定染色体异常定义的B细胞慢性淋巴细胞白血病的预后亚组。
N Engl J Med. 1990 Sep 13;323(11):720-4. doi: 10.1056/NEJM199009133231105.
10
Chromosome aberrations in B-cell chronic lymphocytic leukemia. Pathogenetic and clinical implications.B 细胞慢性淋巴细胞白血病中的染色体畸变。发病机制及临床意义。
Cancer Genet Cytogenet. 1990 Apr;45(2):143-60. doi: 10.1016/0165-4608(90)90079-p.
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