Raess K M, Wegmann W, Huber A K
Chirurgische Klinik, Kantonsspital Bruderholz.
Helv Chir Acta. 1994 Apr;60(4):581-6.
The nephroblastoma-like adenoma of the kidney is an extremely rare tumor with similarities to the nephroblastoma (Wilm's tumor) of the adult. In the literature, different terms are applied to these lesions. We present the case of a 64-year-old woman who underwent a nephrectomy for suspicion of renal cell carcinoma. Histologically the tumor consisted of tubular and papillary formations of monomorphic tumor cells without mitoses or cell-atypias and showed no fibrous capsule. The differential diagnosis to the nephroblastoma of the adult was difficult. Immunohistochemically the tumor expressed the embryonic form of the neural cell adhesion molecule (N-CAM) interstitially and not in the epithelial tumor cell as seen in Wilm's tumor. For the biologic tumor-definition it is important to collect and follow these very rare cases.
肾母细胞瘤样肾腺瘤是一种极其罕见的肿瘤，与成人肾母细胞瘤（威尔姆斯瘤）有相似之处。在文献中，这些病变有不同的命名。我们报告一例64岁女性，因怀疑肾细胞癌而接受肾切除术。组织学上，肿瘤由单形性肿瘤细胞构成的管状和乳头状结构组成，无核分裂或细胞异型性，且无纤维包膜。与成人肾母细胞瘤的鉴别诊断困难。免疫组化显示，该肿瘤间质表达神经细胞黏附分子（N-CAM）的胚胎形式，不像威尔姆斯瘤那样在上皮肿瘤细胞中表达。为了从生物学角度定义肿瘤，收集并随访这些极为罕见的病例很重要。
