Bunnag D, Karbwang J, Thanavibul A, Chittamas S, Ratanapongse Y, Chalermrut K, Bangchang K N, Harinasuta T
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Bangkok, Thailand.
Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):218-9. doi: 10.1016/0035-9203(94)90305-0.
The efficacy of low dose chloroquine, characteristic pattern of relapse and the relapse rate in vivax malaria after high dose primaquine were investigated in 167 Thai patients. 87 patients were allocated at random to receive 300 mg, and 80 received 450 mg of chloroquine on the first day of admission. All patients in both groups showed a rapid response with comparable fever clearance times (27.3 vs. 26.1 h) and parasite clearance times (67.1 vs. 58.1 h). After recovery and clearance of parasitaemia, the patients were allocated at random (double blind) to receive 2 dosage regimens of primaquine, a daily dose of 15 mg or 22.5 mg for 14 d. Relapses in both groups occurred within 6 months; no patient relapsed beyond that period. The relapse rate in the primaquine 15 mg group was significantly higher than that in the 22.5 mg group (17.5% vs. 2.4%).
在167名泰国患者中研究了低剂量氯喹的疗效、间日疟高剂量伯氨喹治疗后的复发特征模式及复发率。87名患者入院首日随机分配接受300mg氯喹，80名患者接受450mg氯喹。两组所有患者均迅速起效，发热清除时间（27.3小时对26.1小时）和寄生虫清除时间（67.1小时对58.1小时）相当。寄生虫血症恢复和清除后，患者随机（双盲）分配接受两种伯氨喹给药方案，每日剂量15mg或22.5mg，共14天。两组复发均发生在6个月内；无患者在此之后复发。伯氨喹15mg组的复发率显著高于22.5mg组（17.5%对2.4%）。
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