Chen R T, Rastogi S C, Mullen J R, Hayes S W, Cochi S L, Donlon J A, Wassilak S G
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333.
Vaccine. 1994 May;12(6):542-50. doi: 10.1016/0264-410x(94)90315-8.
Immunizations against most vaccine-preventable diseases will be needed indefinitely unless the disease is eradicated. Public acceptance of immunizations may be threatened as vaccine coverage increases and disease decreases, however, due to the increase in both causally and coincidentally related vaccine adverse events. The post-marketing surveillance for such events in the USA in response to the mandatory reporting requirements of the National Childhood Injury Act of 1986. While VAERS has many methodological limitations intrinsic to such systems, it can play an important role in helping to monitor vaccine safety and maintain public confidence in immunizations.
除非某种疾病被根除，否则针对大多数可通过疫苗预防的疾病的免疫接种将是长期需要的。然而，随着疫苗接种覆盖率的提高和疾病的减少，公众对免疫接种的接受度可能会受到威胁，这是因为因果相关和偶合相关的疫苗不良事件都有所增加。美国根据1986年《全国儿童伤害法》的强制报告要求对这类事件进行上市后监测。虽然疫苗不良事件报告系统（VAERS）有此类系统固有的许多方法学局限性，但它在帮助监测疫苗安全性和维持公众对免疫接种的信心方面可以发挥重要作用。
