Davis J S
Department of Obstetrics and Gynecology, University of Kansas School of Medicine-Wichita.
Curr Opin Obstet Gynecol. 1994 Jun;6(3):254-61.
The binding of luteinizing hormone/chorionic gonadotropin (LH/CG) to its receptor leads to an orderly cascade of events leading to activation of cytoplasmic effector molecules. The mechanism of action of LH includes stimulation of multiple signal transduction effector systems, including adenylyl cyclase (AC) and inositol phospholipid-specific phospholipase-C (PLC). These effector systems operate by activating families of protein kinases (PKs) which regulate cell metabolism, secretion, gene induction, cellular proliferation and differentiation. The signaling pathways activated by LH interact or cross-talk with the signaling pathways activated by growth factors. The diversity of cellular signaling mechanisms elicited by LH and the potential for interactions with signals generated by growth factors may allow fine tuning of cellular responses during the process of follicular development, ovulation, and corpus luteum formation.
促黄体生成素/绒毛膜促性腺激素（LH/CG）与其受体的结合会引发一系列有序的事件，从而激活细胞质效应分子。LH的作用机制包括刺激多种信号转导效应系统，包括腺苷酸环化酶（AC）和肌醇磷脂特异性磷脂酶C（PLC）。这些效应系统通过激活调节细胞代谢、分泌、基因诱导、细胞增殖和分化的蛋白激酶（PK）家族来发挥作用。LH激活的信号通路与生长因子激活的信号通路相互作用或相互影响。LH引发的细胞信号传导机制的多样性以及与生长因子产生的信号相互作用的可能性，可能使卵泡发育、排卵和黄体形成过程中的细胞反应得到微调。
