Watson J E, Tagupa E T
Department of Internal Medicine, Medical University of South Carolina, Charleston 29425.
Ann Pharmacother. 1994 Apr;28(4):467-9. doi: 10.1177/106002809402800409.
To report a suicide attempt with an aspirin enema.
A patient presented to the emergency room after self-administering, in enema form, approximately 700 aspirin tablets dissolved in water. Over the next 12 hours the patient became progressively acidemic with eventual cardiac arrest and subsequent chronic hypoxic encephalopathy.
This patient's poor outcome was the result of retained aspirin products in the rectal vault combined with the failure to recognize the delayed absorption properties of rectally administered aspirin.
In rectal aspirin overdoses, aspirin absorption from the rectum may occur over a long period of time. It is important to remove as much aspirin from the rectum as possible and to closely monitor these patients so that appropriate therapy may be started quickly. Activated charcoal given both in enema and oral form may help decrease aspirin absorption. Hemodialysis should be available and performed without delay should the patient require it.
报告一例使用阿司匹林灌肠剂自杀未遂的病例。
一名患者自行将约700片溶于水的阿司匹林制成灌肠剂后前往急诊室。在接下来的12小时内,患者逐渐出现酸血症,最终心脏骤停并继发慢性缺氧性脑病。
该患者预后不良是由于直肠内残留阿司匹林制剂,以及未能认识到直肠给药阿司匹林的延迟吸收特性所致。
在直肠阿司匹林过量的情况下,阿司匹林可在较长时间内从直肠吸收。尽可能从直肠清除更多的阿司匹林并密切监测这些患者非常重要,以便能迅速开始适当的治疗。灌肠和口服活性炭可能有助于减少阿司匹林的吸收。应做好血液透析准备,若患者需要应立即进行。