Shi J J, Wang Y P, Sun W Z, Hung C P, Cherng Y G, Lin S Y, Liu C C
Department of Anesthesiology, National Taiwan University Hospital, Taipei, R.O.C.
Acta Anaesthesiol Sin. 1994 Jun;32(2):95-8.
In order to investigate the possible antiemetic property of propofol at subhypnotic dosage, fifty patients scheduled for elective cesarean section under spinal anesthesia were accepted into the study. Patients were randomly given intravenous propofol 10 mg (group I) or 1 ml intralipid (group II) after delivery of the infant. Overall incidence of nausea (24% in group I and 40% in group II) and vomiting (16% in group I and 20% in group II) were not statistically different in the two groups. However, onset time to the appearance of nausea and vomiting were longer in group I (14 +/- 5.8 min vs 5.4 +/- 3.6 min). In conclusion, low dose propofol (10 mg) administered during spinal anesthesia for cesarean section failed to reduce the incidence of emesis.
为了研究丙泊酚在亚催眠剂量下可能的止吐特性，五十例计划在脊麻下行择期剖宫产的患者纳入本研究。婴儿娩出后，患者被随机静脉给予丙泊酚10毫克（I组）或1毫升脂肪乳（II组）。两组恶心（I组24%，II组40%）和呕吐（I组16%，II组20%）的总体发生率无统计学差异。然而，I组恶心和呕吐出现的起始时间更长（分别为14±5.8分钟和5.4±3.6分钟）。总之，剖宫产脊麻期间给予低剂量丙泊酚（10毫克）未能降低呕吐发生率。
