从植物中分离出的一种膜蛋白聚糖的实验性厌食作用
Experimental anorexigenic effect of a membrane proteoglycan isolated from plants.
作者信息
Upreti R K, Ahmad S, Shukla S, Kidwai A M
机构信息
Biomembrane Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
出版信息
J Ethnopharmacol. 1994 Mar;42(1):53-61. doi: 10.1016/0378-8741(94)90023-x.
The cessation of eating under normal physiological conditions is a voluntary act induced by a conscious sensation known as satiety. In pathological situations there is loss of appetite or anorexia. We have been able to isolate and characterize a proteoglycan from membranes of mono- and dicotyledonous plant sprouts which reduced the food intake significantly when injected into murine model systems without any rebound. Due to its membrane origin, it has been termed 'satiomem'. The plant proteoglycan (50 kDa) consisted of 70-85% carbohydrates and 15-30% proteins.
在正常生理条件下，进食的停止是一种由称为饱腹感的自觉感觉引发的自主行为。在病理情况下，会出现食欲不振或厌食。我们已经能够从单子叶和双子叶植物芽的膜中分离并鉴定出一种蛋白聚糖，当将其注射到小鼠模型系统中时，它能显著减少食物摄入量，且没有任何反弹。由于其来源于膜，它被称为“饱腹素膜”。这种植物蛋白聚糖（50千道尔顿）由70 - 85%的碳水化合物和15 - 30%的蛋白质组成。
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