Sidibe S, Frouin F, Bazine J P, Lumbroso J, Schlumberger M, Parmentier C, Di Paola R
Unité de Médecine Nucléaire, INSERM, Institut Gustave-Roussy, Villejuif, France.
Nucl Med Commun. 1994 May;15(5):367-78. doi: 10.1097/00006231-199405000-00008.
Simultaneous investigations with two isotopes are currently restricted because of spectral overlap. The factor analysis of spectral and dynamic structures (FASDS) method is shown to achieve accurate spectral separation. In addition, it estimates underlying dynamic mechanisms. Twenty-six patients were injected simultaneously with 99Tcm-pertechnetate and 201Tl-chloride to assess the malignancy of solitary thyroid nodules. List-mode acquisition of spectral, temporal and spatial coordinates of events allows the reconstruction of an image sequence indexed by time and energy. FASDS proceeds in two steps. First it yields both dynamic and spatial information related to each isotope (99Tcm and 201Tl) and partially removes the scatter component. Then it estimates the underlying kinetics and associated spatial distributions of each isotope. Using the 201Tl component, an index was derived from the uptake ratio between nodules and normal thyroid tissue. Concerning the detection of malignant nodules the method indicated no false negative in our limited group of 26 patients. One false positive result was found which could not be classified by the investigation of the 201Tl dynamic components contained in the reconstructed 201Tl factor sequence.
由于光谱重叠，目前同时使用两种同位素进行的研究受到限制。光谱与动态结构因子分析（FASDS）方法被证明能实现准确的光谱分离。此外，它还能估计潜在的动态机制。26名患者同时注射了高锝[99Tcm]酸盐和氯化铊[201Tl]，以评估孤立性甲状腺结节的恶性程度。对事件的光谱、时间和空间坐标进行列表模式采集，可重建按时间和能量索引的图像序列。FASDS分两步进行。首先，它产生与每种同位素（99Tcm和201Tl）相关的动态和空间信息，并部分去除散射成分。然后，它估计每种同位素的潜在动力学和相关的空间分布。利用201Tl成分，从结节与正常甲状腺组织的摄取率得出一个指数。关于恶性结节的检测，在我们26名患者的有限组中，该方法未显示假阴性结果。发现了一个假阳性结果，通过对重建的201Tl因子序列中包含的201Tl动态成分进行研究无法对其进行分类。
