Hagiwara K, Toyama K, Miyazato H, Nonaka S
Department of Dermatology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan.
J Dermatol. 1994 May;21(5):358-62. doi: 10.1111/j.1346-8138.1994.tb01753.x.
A 65-year-old man presented in 1992 with multiple papular lesions on the scrotum and foreskin. His medical history revealed that, at the age of 25, he was diagnosed as having filariasis and treated conservatively at a hospital in Hawaii. The histologic study of the scrotal skin showed large, dilated vascular spaces in the upper dermis lined with a single layer of endothelial cells that were negative for Factor 8-related antigen. The diagnosis was acquired lymphangioma due to a suspected old filariasis infestation, although serologic tests for filarial antibodies were negative. The paper also presents a review of the literature of acquired lymphangioma in Japan with a brief discussion of etiology and nomenclature.