Lebech M, Larsen S O, Petersen E
Department of Infection-Immunology, Statens Seruminstitut, Copenhagen, Denmark.
Scand J Infect Dis. 1993;25(6):751-6. doi: 10.3109/00365549309008574.
The purpose of this study was to determine the prevalence and incidence of toxoplasmosis in pregnant women in Denmark, and to estimate the incidence of congenital toxoplasmosis. Consecutive serum samples from 5,402 women were analysed for specific IgG and IgM Toxoplasma gondii antibodies by EIA. The prevalence of IgG antibodies was 27.4%. The seroconversion rate was estimated to be 1.16% per year (SE = 0.0017) in all age groups, consistent with an incidence of acute toxoplasmosis in pregnant women of 0.65%. Specific IgM antibodies were present in sera from 29 women. Based on an assumed maternofetal transmission rate of 50%, the incidence of congenital toxoplasmosis was estimated to be 0.33%. Based on these data it is predicted that about 410 pregnant women are infected with T. gondii every year in Denmark, and that about 200 children every year are infected in utero by T. gondii. There was no difference in the prevalence of antibodies in women from rural or urban areas, or from different parts of Denmark.
本研究的目的是确定丹麦孕妇弓形虫病的患病率和发病率，并估算先天性弓形虫病的发病率。采用酶免疫分析法（EIA）对5402名妇女的连续血清样本进行了特异性弓形虫IgG和IgM抗体分析。IgG抗体的患病率为27.4%。所有年龄组的血清转化率估计为每年1.16%（标准误=0.0017），这与孕妇急性弓形虫病的发病率0.65%一致。29名妇女的血清中存在特异性IgM抗体。基于假定的母婴传播率50%，先天性弓形虫病的发病率估计为0.33%。根据这些数据预测，丹麦每年约有410名孕妇感染弓形虫，每年约有200名儿童在子宫内感染弓形虫。丹麦农村或城市地区以及不同地区的妇女抗体患病率没有差异。
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