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[细胞毒性治疗后恶性复发问题]

[The problem of malignant deuteropathy following cytostatic therapy].

作者信息

Gärtner U, Schief A, Stocker W G

出版信息

MMW Munch Med Wochenschr. 1975 Apr 18;117(16):671-6.

PMID:805927
Abstract

Among 17,676 patients admitted to our clinic between 1965 and 1974, we have observed 22 cases of malignant deuteropathy-either after cytostatic therapy or radiation, or as "spontaneous" primary multiple tumors. Their catamneses were analyzed. Seven cases raise a strong suspicion that cytostatic therapy may have induced a cancer. A statistical analysis is not possible with our group of patients. To avoid an inadmissible evaluation of these individual observations, they were compared with the 10 "spontaneous" double tumors observed during the same period. Advances in our knowledge of this field are, in our opinion, to be expected of central cancer registers.

摘要

在1965年至1974年间入住我们诊所的17676名患者中,我们观察到22例恶性发育异常病例——这些病例要么发生在进行细胞抑制治疗或放疗之后,要么是作为“自发”的原发性多发性肿瘤出现。我们对这些病例的病史进行了分析。有7例病例强烈怀疑细胞抑制治疗可能诱发了癌症。对我们这组患者无法进行统计分析。为避免对这些个别观察结果进行不可接受的评估,我们将它们与同期观察到的10例“自发”双肿瘤病例进行了比较。我们认为,该领域知识的进步有望来自中央癌症登记处。

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