Hernigou P, Marce D, Julieron A, Marinello G, Dormont D
Chirurgie Orthopédique, Hôpital Henri Mondor, Créteil.
Rev Chir Orthop Reparatrice Appar Mot. 1993;79(6):445-51.
An experimental study was performed to investigate the efficacy of irradiating HIV-contaminated allografts. Irradiation was achieved using an accelerator delivering 6.3 MeV electrons, and the viral strain was HIV-1/LAV-1. At an activity equivalent to 600.000 counts of reverse transcriptase activity per minute and per millilitre, irradiation permitted total inactivation of HIV. In the light of present data concerning plasma viremia in HIV-infected patients, this experiment suggested that irradiation minimizes as far as possible the risk of transmitting HIV infection through bone transplantation from a seronegative, contaminant donor. However, in view of the relative imprecision of viral sensitivity curves, irradiation does not authorize bone transplantation from a seropositive patient, even though the bone has been irradiated.
进行了一项实验研究，以调查对受HIV污染的同种异体移植物进行辐照的效果。使用一台产生6.3 MeV电子的加速器进行辐照，病毒株为HIV-1/LAV-1。在相当于每分钟每毫升600,000次逆转录酶活性计数的活性水平下，辐照可使HIV完全失活。根据目前有关HIV感染患者血浆病毒血症的数据，该实验表明，辐照可尽可能降低通过骨移植从血清学阴性的污染供体传播HIV感染的风险。然而，鉴于病毒敏感性曲线相对不精确，即使骨已接受辐照，辐照也不允许使用血清学阳性患者的骨进行移植。
