[1989年至1991年期间通过支气管镜检查的HIV感染患者中的卡氏肺孢子虫肺炎]

[Pneumocystis carinii pneumonia in HIV-infected patients examined by bronchoscopy during the period 1989-1991].

作者信息

Jensen A M, Lundgren J D, Nielsen T L, Benfield T L, Vestbo J

机构信息

Infektionsmedicinsk afdeling, Hvidovre Hospital, København.

出版信息

Ugeskr Laeger. 1994 Jul 18;156(29):4241-4.

PMID:8066923

Abstract

We analyzed prospectively collected data from 211 HIV-infected patients who underwent bronchoscopy because of pulmonary symptoms during the period 1989-1991. We found an improvement in survival for patients diagnosed with Pneumocystis carinii pneumonia (PCP) in 1991 as compared to 1989 and 1990 (log rank test: p = 0.07). A significant decline in PO2 and CD4 cell count was observed in patients with PCP in the same period (p < 0.05 and 0.005 respectively). We suggest that the decline in CD4 cell count and in PO2 may reflect a change in Pneumocystis carinii transmission, and that the improved survival may be a result of altered treatment strategy of PCP.

摘要

我们分析了1989年至1991年期间因肺部症状接受支气管镜检查的211例HIV感染患者的前瞻性收集数据。我们发现，与1989年和1990年相比，1991年被诊断为卡氏肺孢子虫肺炎（PCP）的患者生存率有所提高（对数秩检验：p = 0.07）。同期PCP患者的PO2和CD4细胞计数显著下降（分别为p < 0.05和0.005）。我们认为，CD4细胞计数和PO2的下降可能反映了卡氏肺孢子虫传播的变化，而生存率的提高可能是PCP治疗策略改变的结果。